Human Papillomavirus Type 16 E5 Protein as a Therapeutic Target
نویسندگان
چکیده
منابع مشابه
Human Papillomavirus Type 16 E5 Protein as a Therapeutic Target
Cervical cancer is a progressive disease with an onset of one to two decades on average. During the productive replication stage, the Human papillomavirus (HPV) genome is maintained episomally in the infected cervical epithelium and early gene products, including E5, are expressed. Therefore, E5 has a potential to contribute to the HPV-associated carcinogenic process. In invasive malignancies, ...
متن کاملRetraction: Human Papillomavirus Type 16 E5 Protein as a Therapeutic Target. Yonsei Med J 2006;47(1):1-14
I deeply regret to inform you and request for retraction of our review paper published in YMJ.1 We have applied for the U.S. patent with some ideas and research data which are related to the review paper. Upon request from a patent lawyer’s office, we checked the references used in our paper for the Information Disclosure Statement (IDS). We realized that our review paper plagiarized several se...
متن کاملMembrane orientation of the human papillomavirus type 16 E5 oncoprotein.
The E5 protein of human papillomavirus type 16 is a small, hydrophobic protein that localizes predominantly to membranes of the endoplasmic reticulum (ER). To define the orientation of E5 in these membranes, we employed a differential, detergent permeabilization technique that makes use of the ability of low concentrations of digitonin to selectively permeabilize the plasma membrane and saponin...
متن کاملE5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I.
Papillomaviruses have evolved mechanisms that result in escape from host immune surveillance. The E5 protein is expressed early in papillomavirus infection in the deep layers of the infected epithelium. It is localized to the Golgi apparatus (GA) and endoplasmic reticulum. The E5 protein of bovine papillomavirus (BPV) impairs the synthesis and stability of major histocompatibility (MHC) class I...
متن کاملHuman Papillomavirus 16 E5 Modulates the Expression of Host MicroRNAs
Human papillomavirus (HPV) infection is a prerequisite of developing cervical cancer, approximately half of which are associated with HPV type 16. HPV 16 encodes three oncogenes, E5, E6, and E7, of which E5 is the least studied so far. Its roles in regulating replication and pathogenesis of HPV are not fully understood. Here we utilize high-throughput screening to coordinately investigate the e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Yonsei Medical Journal
سال: 2006
ISSN: 0513-5796
DOI: 10.3349/ymj.2006.47.1.1